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Five-Year Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Women: A Systematic Review and Meta-Analysis 

Thursday, February 5, 2026

Submitted by

EACTS Staff

Source

Source Name: European Journal of Cardio-Thoracic Surgery

Source URL: https://academic.oup.com/ejcts/article-abstract/67/12/ezaf400/8322754?redirected…

Author(s)

Seth E. M. Wolf, John A Kucera, Alexander C. Gregg, Antonino Di Franco, Mohamed Rahouma, Bjorn Redfors, Michael Reardon, Andres M. Pineda, Jeffrey G. Gaca, Brittany A. Zwischenberger

A systematic review and meta-analysis of six randomized controlled trials examined five-year outcomes comparing transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR) in 3,094 women with aortic stenosis (1,587 TAVR, 1,507 SAVR). The primary outcome, a composite of all-cause mortality or disabling stroke, showed no significant difference between groups. Meta-regression found no association between clinical covariates and outcomes. Trial sequential analysis confirmed adequate sample size but not a definitive treatment effect. While TAVR shows one-year advantages in women, five-year outcomes are equivalent. The authors conclude that future studies require sex-specific reporting to inform personalized treatment strategies.