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Journal and News Scan

Source: Surgery 
Author(s): Stephanie Lam, Maxime P. Cannesson, Antonia Osuna-Garcia, Edward H. Livingston

This systematic review and meta-analysis evaluated whether preprocedural fasting reduces the risk of witnessed pulmonary aspiration. Across 2,105 patients, aspiration was rare and not influenced by liberal vs restrictive fasting regimens (odds ratio 1.17, 95 percent CI 0.32–4.23). Trial sequential analysis indicated that further studies are unlikely to change this conclusion. Most prior evidence supporting fasting relied on surrogate outcomes such as gastric volume and pH, which have never been shown to correlate with clinical aspiration. The authors conclude that there is no evidence linking liberal fasting to aspiration and suggest that fasting policies could be liberalized, potentially guided by bedside gastric ultrasound. 

Source: British Medical Journal 
Author(s): Sati Heer-Stavert

In this article from the British Medical Journal, the author examines AI-generated images of doctors using OpenAI’s ChatGPT, comparing these depictions with real-world medical workforce data. A total of 24 images were generated, with eight images each for NHS, UK, and US doctors across different specialties. The results showed that only 25 percent of the generated images depicted female doctors, with women appearing in specialties such as obstetrics and pediatrics. In terms of ethnicity, 75 percent of US doctors were shown as white. Notably, images generated with the NHS prompt predominantly featured ethnic minority doctors, while those with the UK prompt depicted white doctors. 

Source: Journal of Cardiothoracic Surgery
Author(s): Mohamed Saad Rakab, Ameer Awashra, Nada Radwan, Abdalhakim Shubietah, Alaa Maamoun, Mohab Mattar, AlMothana Manasrah, Abdelrahman Ghanem, Abdelrahman Elbaz, Ali Emara, Hamza A. Abdul-Hafez

A meta-analysis of nine studies involving 8,557 patients found that early chest tube removal after cardiac surgery was associated with a higher risk of pericardial effusion, although it resulted in shorter hospital stays without significant differences in mortality or postoperative infections. The findings suggest that while early removal may be safe in terms of mortality and infections, it should be approached with caution and monitored closely for potential complications.  

Source: The Journal of Thoracic and Cardiovascular Surgery
Author(s): Magda Piekarska, Manikantam Gaddam, Marcin Malinowski, Austin Goodyke, Boguslaw Gaweda, Manuel Rausch, Tomasz A. Timek

This novel study examined tricuspid annular (TA) remodeling in conscious, awake sheep with functional tricuspid regurgitation (FTR) using tachycardia-induced cardiomyopathy. Fifteen sheep underwent thoracotomy with sonomicrometry crystal implantation around the TA and right ventricular epicardium. Eight surviving animals had baseline measurements acquired while awake, then underwent pacing (180-240 bpm for 18±2 days) until developing FTR. The model produced moderate-severe FTR, with a 48 percent increase in right ventricular (RV) volume, a 57 percent enlargement of the TA area, and a 24 percent perimeter expansion. Critically, all annular segments dilated significantly: the anterior perimeter increased by 27 percent, the posterior perimeter increased by 17 percent, and the septal perimeter by 25 percent (all p<0.01), with the TA area contraction decreasing from 16.6 percent to 4.5 percent. The authors conclude that septal annular dilation, which has traditionally been unsupported by partial rings, may explain high annuloplasty failure rates, suggesting that complete annular support could improve surgical durability in severe FTR. 

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Leo Pölzl, Ronja Lohmann, Clemens Engler, Maria Ioannou-Nikolaidou, Felix Nägele, Jakob Hirsch, Michael Graber, Vanessa Heim, Sophia Schmidt, Ludwig Müller, Daniel Höfer, Johannes Holfeld, Lena Tschiderer, Michael Grimm, Nikolaos Bonaros, Can Gollmann-Tepeköylü

In this propensity score matched analysis of 1,531 patients undergoing mitral valve surgery, women presented at an older age, with more advanced symptoms and more complex valve pathology than men. Female patients more frequently exhibited Carpentier type IIIA disease, annular calcification, and concomitant tricuspid involvement, resulting in lower rates of mitral valve repair and minimally invasive surgery. Women experienced higher mortality rates at 30 days and five years. However, after adjusting for valve morphology, calcification, and surgical strategy, sex was no longer an independent predictor of repair rates or long-term survival. These findings indicate that adverse outcomes in women are primarily driven by delayed referrals and more complex disease rather than sex itself, highlighting the need for earlier recognition and intervention. 

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Markus Kofler, Paolo Berretta, Nikolaos Bonaros, Giovanni Domenico Cresce, Mauro Rinaldi, Antonios Pitsis, Tom C Nguyen, Torsten Doenst, Manuel Wilbring, Marc Gerdisch, Joseph Lamelas, Frank Van Praet, Tristan Yan, Davide Pacini, Antonio Fiore, Nguyen Hoang Dinh, Pierluigi Stefano, Jörg Kempfert, Marco Di Eusanio

This study from the Mini-Mitral International Registry (2015-2021) compared endo-aortic balloon occlusion (EABO) to transthoracic clamping (TTC) in minimally invasive mitral valve surgery. After propensity matching 733 pairs from 6,884 patients, EABO showed significantly lower rates of conversion to sternotomy, although it was associated with longer cardiopulmonary and intubation times. Mortality, stroke, bleeding, vascular complications, ICU stay, and hospital length were similar between the groups. The authors concluded that both techniques are excellent options, but EABO reduces sternotomy conversion rates. 

Source: The Journal of Thoracic and Cardiovascular Surgery
Author(s): Alexander R. Berg, Aravind Krishnan, Elbert E. Heng, Ashley Y. Choi, Alice Zhou, Daniel I. Alnasir, Y. Chawannuch Ruaengsri, Yasuhiro Shudo, Y. Joseph Woo, John W. MacArthur

This retrospective analysis of the UNOS registry investigated patients after the latest allocation revision and examined whether ex vivo heart perfusion (EVHP) mitigated ischemic penalties in adult donation-after-brain-death heart transplants with preservation times of six hours or more. Among 546 recipients who met the criteria (320 receiving EVHP and 226 undergoing static/hypothermic storage), EVHP was associated with superior one-year survival (92.5 percent vs 86.3 percent, p=0.029) and three-year survival (90.9 percent vs 79.6 percent, p<0.001). Multivariable Cox regression confirmed that EVHP reduced the risk of mortality (HR 1.90 for non-EVHP, 95 percent CI 1.08-3.35, p=0.027), with benefits concentrated at high-volume centers. Spline analyses demonstrated an increase in mortality with prolonged preservation in static storage, attenuated by EVHP. The authors conclude that EVHP offsets the survival penalty associated with ischemic times of six hours or more, potentially enabling safer long-distance procurement and broader donor utilization. 

Source: The Doctor
Author(s): Seren Boyd

Alessandro Tamburrini, a consultant thoracic surgeon, reflects on how Professor Peter Altman saved his life as a child with an advanced pelvic rhabdomyosarcoma through innovative treatment and surgery. Inspired by Altman’s compassion and expertise, Tamburrini dedicated his career to medicine, aiming to pay forward the second chance he received.  

Source: European Heart Journal
Author(s): Kevin R. An, Dominique Vervoort, Feng Qiu, Derrick Y. Tam, Rodolfo V. Rocha, Lamia Harik, Sameer Hirji, Sigrid Sandner, Stephen E. Fremes, Harindra C. Wijeysundera, Mario F.L. Gaudino

This propensity score-matched cohort study compared long-term outcomes of percutaneous coronary intervention (PCI) vs coronary artery bypass grafting (CABG) in 2,033 matched pairs of women with chronic severe coronary artery disease. The mean age was 66.5 years, with a median follow-up of 5.1 years. PCI was associated with a significantly higher risk of major adverse cardiovascular and cerebral events (MACCE) compared with CABG (hazard ratio [HR] 1.81). All-cause mortality was also higher after PCI (HR 1.34), as was cardiovascular readmission for myocardial infarction, heart failure, or stroke (HR 1.40). These real-world data show a consistent long-term survival and event-free advantage for CABG over PCI in women with severe chronic coronary artery disease (CAD), supporting CABG as the preferred revascularization strategy in this context. 

Source: European Journal of Cancer
Author(s): Kristof Cuppensa, Marcel Wieswegd, Paul Baasc, Brigitte Maesb, Bert Du Pontg, Till Ploenesh, Dirk Theegartene, Michel Vanbockrijckk, Clemens Aignerh, Koen Harteminkm, Fabian Doerre, Servet Bölükbase, Karin Pata, Martin Schuler

In this study, the authors report the long-term outcomes of the randomized phase II NEOpredict-Lung trial, which evaluates short-course neoadjuvant nivolumab with or without the LAG-3 inhibitor relatlimab in resectable non-small cell lung cancer (NSCLC). Sixty patients with stage IB to IIIA disease received two preoperative cycles of immunotherapy followed by surgery. With a median follow-up of 37 months, the three-year overall survival approached 89 percent in both arms, with durable disease-free survival and low recurrence rates. A major pathological response was associated with improved outcomes. The combination arm showed higher nodal downstaging rates, suggesting a potential added biological effect of LAG-3 blockade. These results support chemotherapy-free neoadjuvant immunotherapy as a feasible and promising strategy, especially in patients who are sensitive to immune checkpoint inhibitors.  

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