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Journal and News Scan
The recent CheckMate 816 trial indicated that neoadjuvant chemo-immunotherapy provided limited local control in stage II–III resectable non-small cell lung cancer (NSCLC). This trial evaluated the hypothesis that incorporating radiotherapy into the treatment plan—involving carboplatin and paclitaxel chemotherapy with neoadjuvant and adjuvant durvalumab—would lead to improved outcomes.
Among 31 patients treated, the major pathologic response (MPR) rate was 63 percent, surpassing the primary endpoint, with a pathologic complete response (pCR) rate of 23 percent. At a median follow-up of 28 months, the two-year progression-free and overall survival rates were 43 percent and 76 percent, respectively. Grade 3 or 4 adverse events occurred in 48 percent of patients, including one treatment-related death.
While this regimen achieved a higher MPR compared to recent perioperative chemo-immunotherapy trials, this did not translate into improved progression-free or overall survival outcomes.
This article addresses the challenges of transitioning from cardiothoracic training to becoming a practicing cardiothoracic surgeon. It discusses the role of additional training in the form of “super-fellowships,” the selection of job opportunities, techniques for building a successful practice, strategies for becoming a productive researcher, and how to transition into a senior career role. This article provides insight from experienced surgeons, as well as advice and strategies to make this transition easier.
This study analyzed long-term risk factors for compensatory sweating following bilateral endoscopic thoracic sympathectomy (BETS) in 98 patients between 2010 and 2023. Compensatory sweating as a side effect was classified as mild, moderate, or severe using the STS guidelines, while quality of life (QOL) was assessed via the Hyperhidrosis Disease Severity Scale. Logistic and Bayesian regression models were used to identify predictors of compensatory sweating.
Overall, the procedure achieved a success rate of 94.38 percent, with 34.69 percent of patients reporting compensatory sweating, mostly mild (26.53 percent). Nearly all patients achieved significant reduction in sweating (≥50 percent in 97.95 percent; ≥80 percent in 94.89 percent).
Protective factors highlighted were high hemoglobin levels and marijuana use. Conversely, tobacco smoking and the presence of combined hand-axillary hyperhidrosis increased the risk of compensatory sweating. Identifying at-risk patients, such as those who smoke tobacco and those with low hemoglobin levels, can help improve outcomes by managing expectations when undergoing (BETS).
The Evolut Low Risk trial demonstrated that transcatheter aortic valve replacement (TAVR) was noninferior to surgery for the primary endpoint of all-cause mortality or disabling stroke at two years. In this new publication, the authors report the five-year outcomes of the Evolut Low Risk trial. In this trial, low-risk patients with severe aortic stenosis were randomly assigned to TAVR or surgery. The primary endpoint was a composite of all-cause mortality or disabling stroke. Secondary endpoints included clinical, echocardiographic, and quality-of-life outcomes through five years.
A total of 1,414 patients underwent attempted valve implantation (n = 730 for TAVR, n = 684 for surgery). The mean age was 74 years (range 51-88 years), and women accounted for 35 percent of the patients. At five years, the Kaplan-Meier estimate for the primary endpoint of all-cause mortality or disabling stroke was 15.5 percent for the TAVR group and 16.4 percent for the surgery group (P = 0.47). The Kaplan-Meier estimates in the TAVR and surgery groups for all-cause mortality were 13.5 percent and 14.9 percent (P = 0.39) and for disabling stroke were 3.6 percent and 4.0 percent (P = 0.57). Cardiovascular mortality was 7.2 percent in the TAVR group and 9.3 percent in the surgery group (P = 0.15). Noncardiovascular mortality in the TAVR group was 6.8 percent and 6.2 percent in the surgery group (P = 0.73). A site-level vital status sweep was performed for patients who were lost to follow-up or withdrew from the study. With the addition of these patients, the all-cause mortality rate at five years for patients undergoing TAVR was 14.7 percent, and for surgery, it was 15.2 percent (P = 0.74). Over five years, the valve reintervention rate was 3.3 percent for TAVR and 2.5 percent for surgery (P = 0.44). A sustained improvement in quality of life was observed in both treatment arms, with a mean Kansas City Cardiomyopathy Questionnaire summary score of 88.3 plus or minus 15.8 in TAVR and 88.5 plus or minus 15.8 in surgery.
This article summarizes the use of artificial intelligence (AI) using ChatGPT to correlate decision-making in a pediatric surgery cardiovascular surgery conference by comparing expert consensus with results from ChatGPT. A total of 37 cases of varying complexity were submitted to ChatGPT, and the software was asked to summarize the case, provide a diagnosis, and suggest a treatment plan, including possible surgical options. Interestingly, there was a consensus on treatment plan approximately 94 percent of the time for simple cases; however, this dropped to only 25 percent for complex cases. This study further highlights the role of AI in medical decision-making, emphasizing its potential as a tool that can aid the medical community and the public in some ways while also cautioning against its pitfalls, which could lead to misinformation and inaccuracies.
This randomized controlled trial explored whether the speed of sternal retraction during cardiac surgery is associated with chronic poststernotomy pain (CPSP). While risk factors such as higher body mass index (BMI), female sex, and younger age are known to be linked to CPSP, no causal determinants have been established.
The study compared slower sternal retraction over 15 minutes to the standard retraction speed of 30 seconds. A total of 313 patients were randomized, with 159 assigned to the slow retraction group and 154 to the standard retraction group. Patients, assessors, and postoperative staff were blinded to the intervention. Pain levels, analgesic use, CPSP incidence, and complications were evaluated at three, six, and 12 months using the Medical Outcomes Survey Short Form.
Results revealed no significant differences in acute pain, CPSP incidence, analgesic consumption, or quality of life outcomes. These findings help rule out sternal retraction speed as a causal factor for CPSP.
This article presents a comprehensive epidemiological analysis of lung cancer, focusing on subtype-specific patterns worldwide. Using data from GLOBOCAN 2022 and other international cancer registries, the study estimated more than 2.48 million new lung cancer cases globally in 2022, with adenocarcinoma being the most common subtype in both men and women. Geographic variation was significant, with East Asia showing the highest incidence of adenocarcinoma and Eastern Europe leading in squamous and small-cell carcinoma among men. Importantly, the study attributed more than 190,000 adenocarcinoma cases to ambient particulate matter (PM) pollution, underscoring the role of environmental exposure in disease burden. Temporal and generational analyses across 19 countries revealed diverse trends in subtype incidence, reflecting evolving risk factors.
This article is important to the global cardiothoracic surgery community as it informs clinical practice, resource planning, and prevention strategies by highlighting shifting patterns in lung cancer subtypes, with implications for early detection and tailored surgical approaches.
This study compared the perioperative and longitudinal risk-adjusted outcomes of patients aged 65 and older with severe aortic stenosis and concomitant coronary artery disease undergoing either coronary artery bypass grafting with surgical aortic valve replacement (CABG+SAVR) or percutaneous coronary intervention with transcatheter aortic valve replacement (PCI+TAVR) from 2018 to 2022. While PCI+TAVR was associated with lower procedural morality, it had higher rates of vascular complications and new permanent pacemaker implantation; however, the five-year composite endpoint favored CABG+SAVR, which resulted in lower rates of stroke, myocardial infarction, valve reintervention, and death. The findings suggest that among Medicare beneficiaries, CABG+SAVR may provide better long-term outcomes compared to PCI+TAVR despite higher procedural morality.
Long-term evidence about bioprosthetic tricuspid valve replacement is scarce. This study aims to investigate the long-term clinical outcomes of patients who underwent tricuspid valve replacement with bioprostheses. This multicenter retrospective study included patients from 10 high-volume centers in seven different countries who underwent tricuspid valve replacement with bioprostheses. Echocardiographic and clinical data were reviewed, and long-term outcomes were investigated. Of the 675 patients, isolated tricuspid valve replacement was performed in 358 patients (53 percent), while 317 (47 percent) underwent concomitant procedures. Between these two groups, patients who underwent combined procedures reported a significantly higher incidence of infection, atrioventricular block, multiorgan failure, longer ICU and hospital stays, and higher 30-day mortality compared to patients who underwent isolated procedures. The overall 30-day mortality occurred in 70 patients (10.4 percent) (46 [14.6 percent] in the combined group vs 24 [6.74 percent] in the isolated group, p = 0.001). During follow-up, there was a continuous rate of attrition due to death, with cumulative incidences of death at five, 10-, and 15-years being 27.2 percent, 46.2 percent, and 60.6 percent, respectively. In contrast, the risk of reintervention started to significantly increase after 10 years of follow-up, with cumulative incidences of reintervention being 6.1 percent, 10.8 percent, and 23.3 percent, respectively. Freedom from tricuspid valve reintervention, pacemaker implantation, tricuspid valve endocarditis, and major thromboembolic events at 15 years were 56.5 percent,77.3 percent, 84.0 percent, and 86.4 percent, respectively. The authors conclude that tricuspid valve replacement with bioprostheses is an effective treatment, despite being associated with relatively high early and long-term mortality. However, the risk of structural valve degeneration rises significantly after 10 years.
This retrospective study compared outcomes in patients undergoing mitral valve repair for valve prolapse, with and without mitral annular disjunction (MAD). After propensity score matching, 100 patients (50 with MAD and 50 without) were analyzed. Hospital mortality was zero percent in both groups, with no significant differences in early reoperation, residual regurgitation, or major arrhythmias. However, patients with MAD showed a greater need for prolonged inotropic and mechanical circulatory support (zero percent vs 10 percent, P=0.050), indicating more frequent early left ventricular dysfunction. Despite this early difference, composite outcomes at midterm follow-up were similar between the groups, suggesting that while MAD presents initial challenges, it does not affect survival at follow-up.